The vast majority of thyroid hormone deficiency is managed with a simple (but monitored) daily intake of exogenous L-thyroxine (“thyroxine” or “T4”), first discovered in its pure porcine extract form at the Mayo Clinic in 1914 and later successfully synthesized by the British scientists, Harington and Barger in 1927.
In the UK, Levothyroxine is available in 25mcg, 50mcg and 100mcg tablet potencies thereby offering convenient dosing, and is prescribed in a range of daily doses from 25mcg up depending on condition, body weight, diet and compliance. Dosing needs to be carefully controlled to achieve normal thyroid stimulating hormone (TSH) levels within normal reference range as long-term TSH suppression to values below normal range will frequently cause cardiac side-effects and contribute to osteoporosis. Levothyroxine is best taken first thing in the morning 30 minutes prior to food or caffeine.
With three iodine molecules, tri-iodothyronine (T3) or liothyronine is the most potent form of thyroxine s and is considered to be the intracellular form of T4. Liothyronine is roughly 4 times more potent than levothyroxine and is used either alone or along side levothyroxine (T4) to managed a hypothyroid condition. Whether or not T3 is prescribed will depend on patient’s ability to convert extraceular T4 to its intracellular form (T3).
Whilst majority of patients respond well to treatment with either synthetic T4 and/or synthetic T3, a certain subset of thyroid patients do not appear to respond well.
Armour Thyroid is available in 2.0gr (120mg), 1.0gr (60mg), 1/2gr (30mg) and 1/4gr (15mg) potencies. Each 1.0gr tablet contains 38mcg of T4 and 9mcg of T3, and is equivalent to 76mcg of synthetic levothyroxine. A prescription only medicine, this product is manufactured to United States Pharmacopeia (USP) standard. Please call 0800 160 1700 for further information.
ERFA is available in 2.0gr (125mg), 1.0gr (65mg), 1/2gr (30mg) potencies. Each 1.0gr contains 35mcg of T4 and 8mcg of T3 and is equivalent to 67mcg of synthetic levothyroxine. A prescription medicine, this product too is produced to USP standard. Please call 0800 160 1700 for further information.
Adrenplus-300 is a glandular preparation; suggested adult daily dose is 1 or 2 capsules or as directed by a healthcare professional. Each capsule contains Adrenal concentrate 150 mg, Spleen concentrate 25 mg, vitamin A 2500 iu, vitamin B1 1.5 mg, vitamin B2 0.75 mg, vitamin B5 30 mg, vitamin B6 25 mg, vitamin C (with bioflavonoids) 150 mg and zinc aspartate 7.5 mg. This product is not intended to diagnose, treat or cure any disease or medical condition. It is considered a supplement.
Life Enhancement Thyroplex This is also a glandular formula containing glandular thyroid, adrenal, hypothalamic, pituitary, and testicular or ovarian tissue with separate formulas for men and women. All principal ingredients are derived from New Zealand livestock where stringent controls have been in place. Manufacturer’s suggested daily dose is one capsule daily in adults. Not recommended for use in children, in pregnancy and during lactation, or in overt and untreated endocrine disease. Note this product is not intended to diagnose, treat or cure any disease or medical condition. It is considered a supplement.
BioCare TH207 is a unique combination of herbs, nutrients and enzymes including the sea vegetable Dulse, Vitamin C, Siberian Ginseng and Niacin and Thiamine and manufactured by a highly reputable company specialising in nutritional supplements. It also provides iodine (from Dulse) and selenium which contribute to the normal thyroid function, and pantothenic acid, vitamin C, niacin, magnesium and manganese which also contribute to normal energy-yielding metabolism. Licorice root is nutritive and helps maintain energy levels. The vitamin B content offers a range of benefits inlcuding but not limited to the release of energy from food, and for the healthy function of the nervous system. Siberian ginseng is a source of antioxidants and may help with energy release. It contains Dulse (Palmaria palmata Seaweed), Vitamin C (as Calcium Ascorbate), Magnesium Gluconate, Siberian Ginseng Powder (Eleutherococcus senticosus Root), Niacin (Vitamin B3 as Nicotinamide), Licorice Powder (Glycyrrhizia Glabra Root), L-Glycine, L-Tyrosine, Thiamine (Vitamin B1 as Thiamine Hydrochloride), L-Glutamine, Modified Tapioca Starch, Potato Maltodextrin, Anti-Caking Agent (Magnesium Stearate), Lipase, Vitamin A (Retinyl Palmitate), Cellulase, Amylase, Protease, L-Selenomethionine, Antioxidant (Natural Mixed Tocopherols1), Sunflower Oil, Soy Protein Isolate1, Capsule Shell (Hydroxypropyl Methylcellulose). The recommeneded daily dose is one capsule taken twice daily with food, or as professionally directed. It is not suitable for use during pregnancy or for planned pregnancy. Note this product too is not intended to diagnose, treat or cure any disease or medical condition. It is a high quality thyroid supplement.
Higher Nature Thyroid Support Formula It is well known that body uses the minerals Iodine and Selenium to make thyroid hormones, essential for heat, energy and metabolism, and proper functioning of other body organs. This formula provides Iodine and Selenium, plus Tyrosine and nine other vitamins and minerals. Manufactured by another highly reputable company offering a range of nutritional products and supplements, this formula provides key nutrients for healthy functioning of the thyroid gland. The manufacturer suggests that it be taken alongside Ocean Kelp for additional thyroid support (but not if taking thyroxine). Again please note this product too is not intended to diagnose, treat or cure any disease or medical condition. It is a high quality thyroid supplement.
THORNE Thyrocsin Formula A non-glandular dietary formula which contains nutrients and botanicals that enhance T4 production for peripheral conversion of T4 to T3 which regulates metabolism of proteins, fats, and carbohydrates, affecting how these compounds produce energy; T4 supports cardiac output, heart rate, respiratory rate, and basal metabolic rate (BMR). A low BMR may cause one to be fatigued, chilly, and have trouble losing weight. Thyrocsin provides supportive nutrients for a healthy thyroid gland. Although Thyrocsin contains nutrients that support healthy thyroid function, it also provides nutrients necessary for conversion of T4 (extracellular thyroxine) to T3 (intracelular thyroxine) in the tissues outside the thyroid gland. Iodine is necessary for formation of T4 and L-tyrosine is a necessary component of both T4 and T3 formation. Animal studies indicate the Ayurvedic botanical ashwagandha can increase T4 concentrations. Several nutrients are also necessary for conversion of T4 to T3, including the minerals selenium, zinc, and copper. Thyrocsin contains vitamin B12 because its insufficiency appears to interfere with the activity of thyroid hormones. Conversion of T4 to T3 can be inhibited by heavy metal toxicity and lipid peroxidation; the antioxidant vitamins C and E can counterbalance this inhibition. High cortisol levels can interfere with thyroid function, resulting in low T4 or poor conversion of T4 to the active form, T3. Therefore nutrients that support normal levels of cortisol may prove beneficial. Note this formula is not intended to diagnose, treat or cure any disease or medical condition. It is a high quality thyroid supplement.
THORNE Iodine & Thyrosine Formula is a hypo-Allergenic dietary supplement made without Flowing Agents that can Inhibit Bioavailability. It is manufacured by Thorne Research and contains essential mineral and amino acid that support the thyroid gland. Ecah capsule contains 225mcg of Iodine as potasssium iodide and 500mg of L-Tyrosine. It is not intended to diagnose, treat or cure any disease or medical condition. It is a high quality thyroid supplement different from Thorne’s Thyrocsin formulation in that it only provides supplementary doses of components necessary for thyroxine production but not conversion of T4 to T3 (see above). The recommended dose is one capsule twice daily or as directed by a healthcare professional.
NOW Thyroid Energy Formula is a complete nutritional supplement for the support of a healthy thyroid gland. NOW has combined Iodine and Tyrosine, the two integral constituents necessary for synthesis of thyroid secretions. The minerals Selenium, Zinc and Copper have been added as cofactors needed for normal thyroid function. In addition, it contains the Ayurvedic herbal extracts from Guggul (Commiphora mukul) and Ashwagandha (Withania somnifera) to complement its nutritional support components. It is not intended to diagnose, treat or cure any disease or medical condition.
Dr Chistopher’s herbal Thyroid Maintenance Formula is a predominently herbal thyroid support formula and contains Kelp, Watercress, Mullein Leaves, Parsley, Nettle Leaves, Irish Moss, Iceland Moss and Sheep Sorrel Herb in pure 100% vegetable-based capsule. According to the manufacturer, this formula assists the thyroid gland with herbs that support it function more efficiently. The recommended daily dose as a dietary supplement is 2 capsules three times a day or as directed by your health care professional. It is not intended to diagnose, treat or cure any disease or medical condition.